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Abstract

The GABRA2 gene encodes a subunit of a GABAA receptor found in the mesolimbic reward circuitry, and modulation of GABAA receptors by alcohol is hypothesized to contribute to the psychotropic properties of the drug. Linkage studies have found a significant correlation between a single nucleotide polymorphism (SNP, rs279858) in the GABRA2 gene and increased risk for alcohol use disorders (AUDs).

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