Towards Selective Poly-ADP-ribose Polymerase Inhibitors Public Deposited

Poly-ADP-ribose-polymerases (PARPs) are a family of 17 post
translationally modifying enzymes in humans that catalyze the
transfer of ADP-ribose from nicotinamide adenine dinucleotide
(NAD+) onto target amino acids and nucleotides. PARPs can append
long dendritic chains of ADP-ribose (poly-ADP-ribosylation, or
PARylation) or monomers of ADP-ribose targets (mono-ADP
ribosylation, or MARylation) to their). While the majority of the PARPs
catalyze MARylation, there has been surprisingly little attention given
to these enzymes or modification the last ten years. Even now, as
evidence of the MARylating PARPs’ importance in basic biology and
human diseases masses, very little is known about the function, targets,
or biological mechanisms of these PARPs. Conversely, the PARylating
PARPs are well understood.

  • ilsa.kirby.2019.pdf
Publication Date
  • 2019
Document type