Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor in adults. Owing to a high level of disease heterogeneity and common recurrence, 5-year survival is below 10% with a near 100% mortality rate. Early and accurate diagnosis of GBM is vital for disease identification, treatment planning, and therapy response assessment. Such diag-noses are often made using dynamic contrast-enhanced magnetic resonance imaging (MRI) and positron emission tomography (PET). These imaging techniques not only outline the anatomical structure of the tumor, but also indicate physiological characteristics including blood flow and oxygen content within its microenvironment. These features are clinically sig-nificant, as disease prognosis and treatment efficacy are modulated by hypervascularization and reduced oxygen content (hypoxia).