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Abstract

Seizures are patterns of abnormal electrical activity in the brain that can result in altered sensory perception, loss of consciousness, and involuntary motor spasms. Epilepsy is the diagnosis of spontaneous and recurrent seizures. Of the many varieties of epilepsy, temporal lobe epilepsy is a common acquired epilepsy in adults and is in many cases medically intractable. Acquired temporal lobe epilepsy can result following brain trauma; however, the mechanism for the development of epilepsy from a precipitating neurological insult has remained elusive. Temporal lobe epilepsy is correlated with altered structure and function of neural circuits, changes that are hypothesized as a primary factor in epilepsy etiology, though it is unclear how individual circuit changes affect excitability in epileptic brains.

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