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Abstract

Historically, the complex anatomical landscape of the central nervous system and the physiology that governs it presented a challenge for scientists interested in elucidating fundamental properties of solute trafficking in the central nervous system. This resulted in a wide range of conflicting models of fundamental physiological processes, such as the production and reabsorption of cerebrospinal fluid in the cranium. Major advances were recently made in the study of solute trafficking between the brain and cerebrospinal fluid, and the reabsorption of cerebrospinal fluid and solutes therein. These findings challenge the previous assumptions about where cerebrospinal fluid (CSF) circulates through the cranium and how it is reabsorbed. The work described in this dissertation aims to address knowledge gaps using a combination of light microscopy, transgenic animal models, and experimental manipulation of physiological parameters that act on this biological system.

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