Evaluation and implementation of a dosimetry protocol for Lutetium Lu 177 DOTATATE for the treatment of gastroenteropancreatic-neuroendocrine tumors Public Deposited

Lutathera is a radiopharmaceutical used to treat gastroenteropancreatic-neuroendocrine tumors(GEP-NETs) in adults that are positive for hormone receptor somatostatin. The cur-rent FDA-approved label describes Lutathera treatment as four 200 mCi cycles given every eight weeks. If the patient reacted negatively to toxicity caused by acute myelosuppression which is a decrease in bone marrow activity which leads to fewer red blood cells, white blood cells, and platelets, or nephrotoxicity(1), the dose is halved to 100 mCi. If the patient continues to experience toxicity from the radiopharmaceutical, the treatment is stopped. A dosimetry protocol will outline the imaging modality utilized to obtain quantitative infor-mation about the distribution of Lutathera, the frequency at which imaging needs to occur, and the time after injection that imaging needs to occur. Personalized dosimetry would also allow for an increase of prescribed activity with the gain in knowledge of the proximity to dose thresholds leading to deterministic effects for organs at risk.

  • https://doi.org/10.6083/pz50gw80v
  • Stoller.Jared.2022.pdf
Publication Date
  • 2022
Document type