Growth and carnitine status of children treated with the ketogenic diet for intractable epilepsy Public Deposited

Long-term treatment with the Ketogenic Diet among children with intractable epilepsy may negatively impact growth, especially linear growth, body composition, and plasma carnitine concentrations. Treatment with the Ketogenic Diet also results in an increased demand for carnitine, which may lead to hypocarnitinemia. As 90% of carnitine is stored in the muscle, the amount of muscle mass in children prior to starting dietary treatment may play a role in the carnitine status of these children. Limited research exists describing the potential relationship between, and potential protective effect of, greater muscle mass and changes in carnitine status in patients treated with the Ketogenic Diet.

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