α2δ proteins (CACNA2D1-4) are auxiliary subunits to voltage-gated calcium channels (VGCCs), and they contribute to VGCC trafficking to the plasma membrane. However, there is now evidence that their roles extend beyond VGCC-dependent function in neurons1. In fact, α2δ-1 promotes excitatory synapse formation in a calcium-independent manner. However, little is known about the potential functional redundancies of α2δ isoforms, or whether they operate pre- or postsynaptically. Thus, we investigated postsynaptic functions of the α2δ-2 proteins (CACNA2D2) in two studies.