Pediatric patients are at risk for morbidity and mortality secondary to medication dosing errors. Unlike with adult dosing, most pediatric medications require weight-based dosing, which increases the need for dosing precision. A common problem is that there are a variety of options for prescribing and dispensing medication(s) for children which raise practice behaviors of providers regarding medication dosing to the forefront of concerns. The adverse effects of some of these prescribed medication classes in pediatrics heighten the level of concern. The two most common prescribed medications in the pediatric population include opioid derivatives and antibiotics. Inaccurate prescribing of both categories of medications can cause significant adverse outcomes including death in children. The purpose of this pre-intervention and post-intervention research study was to evaluate prescriber adherence and satisfaction with a clinical decision support tool which rounded 16 commonly prescribed medications to pre-determined standardized values in order to better facilitate prescribing and dispensing efforts by physicians and pharmacists.