Investigating the feasibility of using a population-based input function for pharmacokinetic modeling of [11C]PBR28 during positron emission tomography studies in a population of methamphetamine users Public Deposited

The innate neuroimmune response is characterized, in part, by proliferation and morphological changes of microglia and astrocytes. Over-activation of microglia results in the production of a number of pro-inflammatory markers and the release of reactive oxygen and nitrogen species that cause neuronal damage. The aims of this thesis were to investigate if there is a significant difference in the tracer plasma concentrations between healthy controls (HC) and MA users and to identify an alternative to arterial Ifs by generating a population-based input functions (PBIF).


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  • https://doi.org/10.6083/7h149q66x
  • Schoen.Devin.2022.pdf
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  • 2022
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