The role of AQP4 and the astrocytic endfoot in CSF-ISF exchange and brain waste clearance Public Deposited

Exchange of cerebrospinal fluid (CSF) with interstitial fluid (ISF) is a recently elaborated pathway by which solutes are trafficked into and out of the brain. This pathway has been implicated as a clearance mechanism for proteins such as amyloid β and tau, prior to pathogenic aggregation, a process characteristic of several neurodegenerative diseases. The mechanisms responsible for CSF-ISF exchange are poorly understood but have been linked to the expression of the astrocytic water channel aquaporin-4 (AQP4). AQP4 is unique in that it exhibits a profound localization to the perivascular spaces at which CSF-ISF exchange occurs, and that pathological states, including aging, dramatically reduce this localization. The significance of this loss of localization for CSF-ISF exchange and neurodegenerative disease has not been articulated. Here, we use imaging and cellular based approaches to study the role of AQP4 and the astrocytic endfoot in CSF-ISF exchange and aggregating protein clearance.

Last modified
  • 11/21/2019
Creator
ORCID
  • 0000-0002-0065-6486
Degree
Institution
School
Publisher
Identifier
  • simon.matthew.2019.pdf
  • 10.6083/6395w780w
Keyword
Publication Date
  • 2019
Document type
Citation
  • Simon, M. J. "The role of AQP4 and the astrocytic endfoot in CSF-ISF exchange and brain waste clearance " (2019). OHSU Digital Collections. simon.matthew.2019.pdf
In Collection:

Items