Development and function of tissue-resident memory CD8+ T cells Public Deposited

Tissue-resident memory (TRM) CD8+ T cells permanently reside within non-lymphoid tissues where they provide a first-line of defense against invading pathogens. How-ever, the mechanisms regulating their development and the long-term functional consequences following their activation in situ are poorly defined. Here, I use a model of epicutaneous Vaccinia virus infection to investigate two main research questions regarding the development and function of TRM CD8+ T cells. I begin by describing the role that antigen recognition within the skin microenvironment plays in the development of TRM CD8+ T cells. Next, I determine how repeated antigen encounters by mature TRM CD8+ T cells impacts the composition and function of the TRM population.


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  • https://doi.org/10.6083/5x21tg13g
  • Hobbs.Samuel.2020.pdf
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Publication Date
  • 2020
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