Chronic morphine treatment induces heterologous alterations in acute kinase-dependent desensitization Public Deposited

Opioids such as morphine are still the most effective analgesics for many types of pain. However, clinical utility of opioids is limited because long-term use leads to analgesic tolerance, such that higher concentrations of opioids are needed to achieve the same analgesic effect. This is problematic since tolerance to the life-threatening respiratory depressive effects of opioids develops slower than to the analgesic effects of opioids. Thus, opioid tolerance increases risk for overdose and death.


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  • Leff.Emily.2020.pdf
  • https://doi.org/10.6083/3197xm82x
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  • 2020
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